Normal bipolar spindle (top), with immunofluorescence-stained chromosomes (blue) aligned in middle, forms in control cells undergoing mitosis. In mitotic cells treated with the potential anticancer agent monastrol (bottom), spindle becomes ringlike, or “monastral,” and cell division is blocked.
"Using a collection of small molecules and a clever screening strategy, Harvard researchers have identified a potential anticancer agent called monastrol that blocks cell division (mitosis) by inhibiting a new target—a motor protein called Eg5. The study could lead not only to a novel class of anticancer drugs, but also to a better fundamental understanding of the mechanism of mitosis." -Stu Borman