Vitamin B12: The struggle toward synthesis

“From beginning to end the chemical odyssey spanned 11 years. Altogether it involved 99 people from 19 countries. It was a collaborative effort, absorbing the attention of laboratories in both Cambridge, Mass., and Zurich, Switzerland. And it spawned numerous by-products, including one of the most significant contributions in the field of organic chemistry—the principle of conservation of orbital symmetry.”

Chemical & Engineering News, March 12, 1973 [pdf]

Notes

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